Human DNA Ligases: A Comprehensive New Look for Cancer Therapy
Identifieur interne : 001063 ( Main/Exploration ); précédent : 001062; suivant : 001064Human DNA Ligases: A Comprehensive New Look for Cancer Therapy
Auteurs : Deependra Kumar Singh [Inde] ; Shagun Krishna [Inde] ; Sharat Chandra [Inde] ; Mohammad Shameem [Inde] ; Amit Laxmikant Deshmukh [Inde] ; Dibyendu Banerjee [Inde]Source :
- Medicinal Research Reviews [ 0198-6325 ] ; 2014-05.
Abstract
Living organisms belonging to all three domains of life, viz., eubacteria, archaeabacteria, and eukaryotes encode one or more DNA ligases. DNA ligases are indispensable in various DNA repair and replication processes and a deficiency or an inhibition of their activity can lead to accumulation of DNA damage and strand breaks. DNA damage, specially strand breaks at unsustainable levels can lead to replication block and/or cell death. DNA ligases as potential anticancer targets have been realized only recently. There is enough rationale to suggest that ligases have a tremendous potential for novel therapeutics including anticancer and antibacterial therapy, specially when the world is facing acute problems of drug resistance and chemotherapy failure, with an immediate need for new therapeutic targets. Here, we review the current state of the art in the development of human ligase inhibitors, their structures, molecular mechanisms, physiological effects, and their potential in future cancer therapy. Citing examples, we focus on strategies for improving the activity and specificity of existing and novel inhibitors by using structure‐based rational approaches. In the end, we describe potential new sites on the ligase I protein that can be targeted for the development of novel inhibitors. This is the first comprehensive review to compile all known human ligase inhibitors and to provide a rationale for the further development of ligase inhibitors for cancer therapy.
Url:
DOI: 10.1002/med.21298
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002C90
- to stream Istex, to step Curation: 002C90
- to stream Istex, to step Checkpoint: 000156
- to stream Main, to step Merge: 001064
- to stream Main, to step Curation: 001063
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Human DNA Ligases: A Comprehensive New Look for Cancer Therapy</title>
<author><name sortKey="Singh, Deependra Kumar" sort="Singh, Deependra Kumar" uniqKey="Singh D" first="Deependra Kumar" last="Singh">Deependra Kumar Singh</name>
</author>
<author><name sortKey="Krishna, Shagun" sort="Krishna, Shagun" uniqKey="Krishna S" first="Shagun" last="Krishna">Shagun Krishna</name>
</author>
<author><name sortKey="Chandra, Sharat" sort="Chandra, Sharat" uniqKey="Chandra S" first="Sharat" last="Chandra">Sharat Chandra</name>
</author>
<author><name sortKey="Shameem, Mohammad" sort="Shameem, Mohammad" uniqKey="Shameem M" first="Mohammad" last="Shameem">Mohammad Shameem</name>
</author>
<author><name sortKey="Deshmukh, Amit Laxmikant" sort="Deshmukh, Amit Laxmikant" uniqKey="Deshmukh A" first="Amit Laxmikant" last="Deshmukh">Amit Laxmikant Deshmukh</name>
</author>
<author><name sortKey="Banerjee, Dibyendu" sort="Banerjee, Dibyendu" uniqKey="Banerjee D" first="Dibyendu" last="Banerjee">Dibyendu Banerjee</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C81056AE8DF46B899FD2CA18BC174C0968045FBF</idno>
<date when="2014" year="2014">2014</date>
<idno type="doi">10.1002/med.21298</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-X8SD8RH5-K/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002C90</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002C90</idno>
<idno type="wicri:Area/Istex/Curation">002C90</idno>
<idno type="wicri:Area/Istex/Checkpoint">000156</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000156</idno>
<idno type="wicri:doubleKey">0198-6325:2014:Singh D:human:dna:ligases</idno>
<idno type="wicri:Area/Main/Merge">001064</idno>
<idno type="wicri:Area/Main/Curation">001063</idno>
<idno type="wicri:Area/Main/Exploration">001063</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Human DNA Ligases: A Comprehensive New Look for Cancer Therapy</title>
<author><name sortKey="Singh, Deependra Kumar" sort="Singh, Deependra Kumar" uniqKey="Singh D" first="Deependra Kumar" last="Singh">Deependra Kumar Singh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>CSIR‐Central Drug Research Institute, B.S. 10/1, Janakipuram Extension, Sitapur Road, Uttar Pradesh, 226021, Lucknow</wicri:regionArea>
<wicri:noRegion>Lucknow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Krishna, Shagun" sort="Krishna, Shagun" uniqKey="Krishna S" first="Shagun" last="Krishna">Shagun Krishna</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>CSIR‐Central Drug Research Institute, B.S. 10/1, Janakipuram Extension, Sitapur Road, Uttar Pradesh, 226021, Lucknow</wicri:regionArea>
<wicri:noRegion>Lucknow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chandra, Sharat" sort="Chandra, Sharat" uniqKey="Chandra S" first="Sharat" last="Chandra">Sharat Chandra</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>CSIR‐Central Drug Research Institute, B.S. 10/1, Janakipuram Extension, Sitapur Road, Uttar Pradesh, 226021, Lucknow</wicri:regionArea>
<wicri:noRegion>Lucknow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shameem, Mohammad" sort="Shameem, Mohammad" uniqKey="Shameem M" first="Mohammad" last="Shameem">Mohammad Shameem</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>CSIR‐Central Drug Research Institute, B.S. 10/1, Janakipuram Extension, Sitapur Road, Uttar Pradesh, 226021, Lucknow</wicri:regionArea>
<wicri:noRegion>Lucknow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Deshmukh, Amit Laxmikant" sort="Deshmukh, Amit Laxmikant" uniqKey="Deshmukh A" first="Amit Laxmikant" last="Deshmukh">Amit Laxmikant Deshmukh</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>CSIR‐Central Drug Research Institute, B.S. 10/1, Janakipuram Extension, Sitapur Road, Uttar Pradesh, 226021, Lucknow</wicri:regionArea>
<wicri:noRegion>Lucknow</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Banerjee, Dibyendu" sort="Banerjee, Dibyendu" uniqKey="Banerjee D" first="Dibyendu" last="Banerjee">Dibyendu Banerjee</name>
<affiliation wicri:level="1"><country xml:lang="fr">Inde</country>
<wicri:regionArea>CSIR‐Central Drug Research Institute, B.S. 10/1, Janakipuram Extension, Sitapur Road, Uttar Pradesh, 226021, Lucknow</wicri:regionArea>
<wicri:noRegion>Lucknow</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Inde</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Medicinal Research Reviews</title>
<title level="j" type="alt">MEDICINAL RESEARCH REVIEWS</title>
<idno type="ISSN">0198-6325</idno>
<idno type="eISSN">1098-1128</idno>
<imprint><biblScope unit="vol">34</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="567">567</biblScope>
<biblScope unit="page" to="595">595</biblScope>
<biblScope unit="page-count">29</biblScope>
<date type="published" when="2014-05">2014-05</date>
</imprint>
<idno type="ISSN">0198-6325</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0198-6325</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">Living organisms belonging to all three domains of life, viz., eubacteria, archaeabacteria, and eukaryotes encode one or more DNA ligases. DNA ligases are indispensable in various DNA repair and replication processes and a deficiency or an inhibition of their activity can lead to accumulation of DNA damage and strand breaks. DNA damage, specially strand breaks at unsustainable levels can lead to replication block and/or cell death. DNA ligases as potential anticancer targets have been realized only recently. There is enough rationale to suggest that ligases have a tremendous potential for novel therapeutics including anticancer and antibacterial therapy, specially when the world is facing acute problems of drug resistance and chemotherapy failure, with an immediate need for new therapeutic targets. Here, we review the current state of the art in the development of human ligase inhibitors, their structures, molecular mechanisms, physiological effects, and their potential in future cancer therapy. Citing examples, we focus on strategies for improving the activity and specificity of existing and novel inhibitors by using structure‐based rational approaches. In the end, we describe potential new sites on the ligase I protein that can be targeted for the development of novel inhibitors. This is the first comprehensive review to compile all known human ligase inhibitors and to provide a rationale for the further development of ligase inhibitors for cancer therapy.</div>
</front>
</TEI>
<affiliations><list><country><li>Inde</li>
</country>
</list>
<tree><country name="Inde"><noRegion><name sortKey="Singh, Deependra Kumar" sort="Singh, Deependra Kumar" uniqKey="Singh D" first="Deependra Kumar" last="Singh">Deependra Kumar Singh</name>
</noRegion>
<name sortKey="Banerjee, Dibyendu" sort="Banerjee, Dibyendu" uniqKey="Banerjee D" first="Dibyendu" last="Banerjee">Dibyendu Banerjee</name>
<name sortKey="Banerjee, Dibyendu" sort="Banerjee, Dibyendu" uniqKey="Banerjee D" first="Dibyendu" last="Banerjee">Dibyendu Banerjee</name>
<name sortKey="Chandra, Sharat" sort="Chandra, Sharat" uniqKey="Chandra S" first="Sharat" last="Chandra">Sharat Chandra</name>
<name sortKey="Deshmukh, Amit Laxmikant" sort="Deshmukh, Amit Laxmikant" uniqKey="Deshmukh A" first="Amit Laxmikant" last="Deshmukh">Amit Laxmikant Deshmukh</name>
<name sortKey="Krishna, Shagun" sort="Krishna, Shagun" uniqKey="Krishna S" first="Shagun" last="Krishna">Shagun Krishna</name>
<name sortKey="Shameem, Mohammad" sort="Shameem, Mohammad" uniqKey="Shameem M" first="Mohammad" last="Shameem">Mohammad Shameem</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001063 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001063 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Main |étape= Exploration |type= RBID |clé= ISTEX:C81056AE8DF46B899FD2CA18BC174C0968045FBF |texte= Human DNA Ligases: A Comprehensive New Look for Cancer Therapy }}
This area was generated with Dilib version V0.6.33. |